About Melinjo Dimer Resveratrol

Melinjo Dimer Resveratrol is a result of more than 10 years of rigorous development work by the leading Japanese ingredients company Hosoda Nutritional.
Melinjo Dimer Resveratrol is a natural resveratrol extracted from the seeds of the melinjo, Gnetum gnemon. This small tree is native to Southeast Asia and melinjo is the common Indonesian name for the plant.

The source of the product originates from the island of Java in Indonesia and each production lot leaving the factory in Japan, where the product is standardized, can be traced back to a single farmer and field in Indonesia.
Melinjo Dimer Resveratrol can be found in a range of consumer products in Japan and is available for food and supplement manufacturers in the European Union and in the United States.

Origin

Melinjo Dimer Resveratrol is a natural resveratrol extracted from the seeds of the melinjo, Gnetum gnemon. This small three is native to Southeast Asia and “melinjo” is the common Indonesian name for the plant. Melinjo has been consumed for centuries by the Indonesian population

The history of Melinjo can be traced back to the Kingdom of Yogyakarta, where the melinjo tree grows in abundance. In this area one can find a high concentration of melinjo trees and expectedly with the highest per capita consumption of melinjo. It may not be a coincidence that the population of Yogyakarta also has the longest life-expectancy in Indonesia, an average 10% higher than the rest of the population.

Melinjo is commonly cultivated throughout Indonesia and the seeds, leaves and flowers are used as an ingredient in many dishes served on important traditional occasions. For instance, the seeds of melinjo are used for producing emping; a cracker, one of the staples in the Indonesian kitchen. Emping can be found in any well-stocked Asian supermarket globally. In addition to the seeds, melinjo tree also provides the farmers with other valuable benefits. It provides shade in the villages making the living conditions more pleasant in the extreme tropical heat. Maybe even more significantly, the melinjo tree is a very important plant in the Indonesian agro-forestry.

Production

Hosoda Nutritional has a long history in Indonesia focusing on natural ingredients from Java. Strong local presence with three regional collection centres and with the new extraction plant in Bandung, Hosoda Nutritional is in a perfect position to source valuable ingredients across the South East Asia.

The final processing and quality assurance takes place in Japan from where products are distributed for the global supplement and cosmetic industries. Hosoda Nutritional is working together with the Indonesian Agricultural Association and local farmers in Indonesia growing the melinjo. This cooperation guarantees full traceability for the ingredient and makes possible to identify the specific farmer and field that has supplied the raw material. This cooperation also guarantees stable revenue to farmers in the form of higher prices for melinjo. For example, in the village of Kediri, Hosoda Nutritional has financed a collection and processing center for the village and is training the operators in regard to food safety and quality to meet the company’s strict requirements.

In the local centers the seeds are sorted by hand, dried, peeled and backed to be transported to the extraction plant in Bandung. This brand-new extraction plant is designed by Japanese and operated by a trained workforce with a focus on quality and food safety. From here the product is shipped to Japan for the final processing and quality control.

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Sales

The two main products sold by Hosoda Nutritional are Melinjo Kokuno Hana and Melinjo Dimer Resveratrol.

Melinjo Kokuno Hana is single strength melinjo flour mainly for food producers. Melinjo Kokuno Hana offers the typical Indonesian flavour to soups, sauces, snacks and other food products. Kokuno Hana is currently sold in Japan for a range of applications. Hosoda Nutritional is able to assist with new product development and other application work

Melinjo Dimer Resveratrol has been in the market in Japan for several years as a food ingredient and the sales are strong. In the Japanese market Melinjo dimer resveratrol is sold in nutritional compounds with other functional ingredients (for example royal jelly) and as a single supplement, Resveratrol+. “Resveratrol+.” Consumer products containing Melinjo Dimer Resveratrol are typically high-end brands for consumers who want to be more active, feel energetic and fight aging.

Hosoda Nutritional is the only company supplying Melinjo Dimer Resveratrol to the Japanese and the global supplement markets. In the United States Hosoda Nutritional is working to get self-affirmed GRAS and this work is expected to be finalized during this year. Hosoda Nutritional has patented Melinjo Dimer Resveratrol Patent No. :US 8,067,036 B2.

Science

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Melinjo seed contains an abundance of resveratrol (stilbenoid) mainly in form of dimers (Gnetin C). Melinjo Dimer Resveratrol has been studied for more than 10 years, principally by Japanese scientists. There is already a good level of clinical documentation and new studies are continuing to emerge.

In addition to Melinjo Dimers anti-oxidative and anti-viral activities it may also reduce visceral fat and increasing stamina in human beings. The recommended daily dosage for the product has not been established. Based on the preliminary studies and current usage a maximum daily dosage of 50mg would be a reasonable level of Melinjo Dimers to start eliciting beneficial effects.

Human Safety Study– According to Human Safety Study that conducted in Japan, Melinjo Seed Extract is considered to be safe. Pharmacokinetics of resveratrol derivatives in healthy volunteers after oral administration of 1,000mg melinjo seed extract (MSE) powder were assessed and compared. The study was conducted for 28 days, resulted that the MSE powder was well-tolerated up to the oral dosing of 5,000mg with no serious adverse events.

Uric Acid Study– According to a latest clinical trial conducted by the Juntendo School of Medicine in Tokyo, Japan, Melinjo Dimer Resveratrol decreases serum uric acid levels in humans. This randomized controlled study demonstrated Melinjo Dimer Resveratrol beneficial effects in healthy adult males. Compared with the placebo control, Melinjo Dimer Resveratrol significantly reduced serum uric acid levels and improved lipid metabolism by increasing HDL cholesterol.

  • Yanagihara M, Yoshimatsu M, Inoue A, Kanno T, Tatefuji T, Hashimoto K. Inhibitory effect of Gnetin C, a resveratrol dimer from Melinjo (Gnetum gnemon), on tyrosinase activity and melanin biosynthesis. Biol Pharm Bull 2012; 35(6):993-996.
  • Kloypan C, Jeenapongsa R, Sri In P, Chanta S, Dokpuang D, Tip Pyang S et al. Stilbenoids from Gnetum macrostachyum Attenuate Human Platelet Aggregation and Adhesion. Phytother Res 2012.
  • Kunimasa K, Ohta T, Tani H, Kato E, Eguchi R, Kaji K et al. Resveratrol derivative rich melinjo Gnetum gnemon L.) seed extract suppresses multiple angiogenesis related endothelial cell functions and tumor angiogenesis. Mol Nutr Food Res 2011; 55(11):1730 – 1734.
  • Kato H, Samizo M, Kawabata R, Takano F, Ohta T. Stilbenoids from the melinjo (Gnetum gnemon L.) fruit modulate cytokine production in murine Peyer’s patch cells ex vivo. Planta Med 2011; 77(10):1027 1034.
  • Ota H, Akishita M, Tani H, et.al. Trans-Resveratrol in Gnetum gnemon Protects against Oxidative-Stress-Induced Endothelial Senescence. J. Nat. Prod., 2013, 75 (7), pp 1242-1247.
  • Tani H., Hikami S., Iiduna S., Yoshimatsu M., Asama T., Ota H., et al.Pharmacokinetics and Safety of Resveratrol Derivatives in Human after Oral Administration of Melinjo (Gnetum gnemon L.) Seed Extract Powder. Journal of Agricultural and Food Chemistry 2014.
  • Konno H., Kanai Y., Katagiri M., Watanabe T., Mori A., Ikuta T., et al.Melinjo (Gnetum gnemon L.) seed extract decreases serum uric acid levels in non-obese Japanese males: a randomized controlled study. Department of Aging Control Medicine, Juntendo University Graduate School of Medicine, Tokyo, Institute for Bee Products and Health Science, Yamada Bee Company Inc., Okayama, 2013.

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